John-michael Sauer : rechercher sur Z-Library

Campagne de collecte 15 septembre 2024 – 1 octobre 2024 C'est quoi, la collecte de fonds?

Le plus grand référentiel d'articles scientifiques au monde. 70,000,000+ d'articles gratuitement.

Campagne de collecte 15 septembre 2024 – 1 octobre 2024

Z-Library est une des plus grandes bibliothèques en ligne dans le monde, avec le stockage de plus de 17,000,000 livres et plus de 84,837,000 articles. Nous encourageons l'accès libre de chacun à la littérature. Aujourd'hui (15 septembre 2024) nous faisons un appel de fonds à tous ceux qui veulent contribuer encore plus au soutien et au développement de notre projet.

Les téléchargements SANS LIMITE sont aussi (au cours de 31 jours après la date de don) disponibles pour TOUS les utilisateurs qui soient en mesure de soutenir le projet pendant la période de collecte de fonds jusqu'au 1 octobre 2024.

C'est quoi, la collecte de fonds?En savoir plus

Livres
Articles (31)
Les plus populaires
Liste
- Liste
- Tableau

1

Clinical Pharmacokinetics of Atomoxetine

John-Michael Sauer, Barbara J. Ring, Dr Jennifer W. Witcher

Journal:

Clinical Pharmacokinetics

Année:

2005

Langue:

english

Fichier:

PDF, 233 KB

english, 2005

2

Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer’s disease

Martin L. Neitzel, Danielle L. Aubele, Jennifer L. Marugg, Jacek J. Jagodzinski, Andrei W. Konradi, Michael A. Pleiss, Balazs Szoke, Wes Zmolek, Erich Goldbach, Kevin P. Quinn, John-Michael Sauer, Eli

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.80 MB

english, 2011

3

Cytotoxicity and genotoxicity of methyleugenol and related congeners — a mechanism of activation for methyleugenol

Jennifer Lewis Burkey, John-Michael Sauer, Charlene A McQueen, I Glenn Sipes

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2000

Langue:

english

Fichier:

PDF, 172 KB

english, 2000

4

Effect of Potent CYP2D6 Inhibition by Paroxetine on Atomoxetine Pharmacokinetics

Belle, Donna J., Ernest, C. Steven, Sauer, John-Michael, Smith, Brian P., Thomasson, Holly R., Witcher, Jennifer W.

Journal:

Journal of Clinical Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 106 KB

english, 2002

5

Preclinical biomarker qualification

Sauer, John-Michael, Porter, Amy C

Journal:

Experimental Biology and Medicine

Année:

2018

Langue:

english

Fichier:

PDF, 115 KB

english, 2018

6

A formulation strategy for gamma secretase inhibitor ELND006, a BCS class II compound: Development of a nanosuspension formulation with improved oral bioavailability and reduced food effects in dogs

Kevin Quinn, Rampurna Prasad Gullapalli, Elaine Merisko-liversidge, Erich Goldbach, Angelina Wong, Gary G. Liversidge, Wherly Hoffman, John-michael Sauer, John Bullock, George Tonn

Journal:

Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 317 KB

english, 2012

7

N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

Simeon Bowers, Gary D. Probst, Anh P. Truong, Roy K. Hom, Andrei W. Konradi, Hing L. Sham, Albert W. Garofalo, Karina Wong, Erich Goldbach, Kevin P. Quinn, John-Michael Sauer, William Wallace, Lan Ngu

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 848 KB

english, 2009

8

Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement

R. Jeffrey Neitz, Andrei W. Konradi, Hing L. Sham, Wes Zmolek, Karina Wong, Ann Qin, Colin Lorentzen, David Nakamura, Kevin P. Quinn, John-Michael Sauer, Kyle Powell, Lany Ruslim, David Chereau, Zhao

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 852 KB

english, 2011

9

Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metabolites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS)

John H. Mullen, Richard L. Shugert, George D. Ponsler, Qimin Li, Bhaskar Sundaram, Heather L. Coales, Joseph E. Yakupkovic, Richard M. LeLacheur, William J. Wheeler, Frank J. Belas, John-Michael Sauer

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2005

Langue:

english

Fichier:

PDF, 372 KB

english, 2005

10

Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition

Christina R. Wilson, John-Michael Sauer, Gary P. Carlson, Reidar Wallin, Michael P. Ward, Stephen B. Hooser

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 200 KB

english, 2003

11

Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat

John-Michael Sauer, Michael P Waalkes, Stephen B Hooser, Robert K Kuester, Charlene A McQueen, I.Glenn Sipes

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 356 KB

english, 1997

12

Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography

Jingqi Bao, Richard L Smith, John-Michael Sauer, Usha Pillai, I.Glenn Sipes

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1997

Langue:

english

Fichier:

PDF, 1.02 MB

english, 1997

13

Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat

John-Michael Sauer, I.Glenn Sipes

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 1.84 MB

english, 1995

14

Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol

Niel C. Hoglen, Edward A. Abril, John-Michael Sauer, David L. Earnest, Robert S. McCuskey, R. Clark Lantz, Scott A. Mobley, Glenn I. Sipes

Journal:

Liver International

Année:

1997

Langue:

english

Fichier:

PDF, 1.62 MB

english, 1997

15

Tolerance Induced by All-trans-Retinol to the Hepatotoxic Effects of Cadmium in Rats: Role of Metallothionein Expression

John-Michael Sauer, Michael P. Waalkes, Stephen B. Hooser, Antonio T. Baines, Robert K. Kuester, I.Glenn Sipes

Journal:

Toxicology and Applied Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 2.45 MB

english, 1997

16

The Interactions between Retinol and Five Different Hepatotoxicants in the Swiss Webster Mouse

Rhonda J. Rosengren, John-Michael Sauer, Stephen B. Hooser

Journal:

Fundamental and Applied Toxicology

Année:

1995

Fichier:

PDF, 1.98 MB

1995

17

Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids

Christina R. Wilson, John-Michael Sauer, Stephen B. Hooser

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 220 KB

english, 2001

18

An ultrastructural evaluation of acute 1-nitronaphthalene induced hepatic and pulmonary toxicity in the rat

John-Michael Sauer, Robert R. Eversole, Carrie L. Lehmann, Dale E. Johnson, Leonard J. Beuving

Journal:

Toxicology Letters

Année:

1997

Langue:

english

Fichier:

PDF, 911 KB

english, 1997

19

Effects of single and multiple dose oral administration of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain and CSF of cynomolgus monkeys

Brigham, Elizabeth, Quinn, Kevin, Motter, Ruth, Hoffman, Wherly, Goldbach, Erich, Kholodenko, Dora, Kwong, Grace, Willits, Chris, Probst, Gary, Gunther, Jane, Adams, Eric, Sauer, John-Michael, Kinney,

Journal:

Alzheimer's & Dementia

Année:

2010

Langue:

english

Fichier:

PDF, 63 KB

english, 2010

20

Monitoring Signaling by the p75 NTR Receptor Utilizing a Caspase-3 Activation Assay Amenable to Small-Molecule Screening

Bradshaw, J. Michael, Nguyen, Lan, Wallace, William, Li, Calvin, Sauer, John-Michael, Bard, Frédérique, Bova, Michael P.

Journal:

Assay and Drug Development Technologies

Année:

2012

Langue:

english

Fichier:

PDF, 909 KB

english, 2012

21

The Predictive Safety Testing Consortium and the Coalition Against Major Diseases

Stephenson, Diane, Sauer, John-Michael

Journal:

Nature Reviews Drug Discovery

Année:

2014

Langue:

english

Fichier:

PDF, 582 KB

english, 2014

22

Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop

Romero, Klaus, Sinha, Vikram, Allerheiligen, Sandra, Danhof, Meindert, Pinheiro, Jose, Kruhlak, Naomi, Wang, Yaning, Wang, Sue-Jane, Sauer, John-Michael, Marier, J. F., Corrigan, Brian, Rogers, James,

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Année:

2014

Langue:

english

Fichier:

PDF, 154 KB

english, 2014

23

The Interactions between Retinol and Five Different Hepatotoxicants in the Swiss Webster Mouse

ROSENGREN, RHONDA J., SAUER, JOHN-MICHAEL, HOOSER, STEPHEN B., SIPES, I. GLENN

Journal:

Toxicological Sciences

Année:

1995

Langue:

english

Fichier:

PDF, 6.17 MB

english, 1995

24

Alterations in Chemically Induced Tissue Injury Related to All- trans -Retinol Pretreatment In Rodents

Sauer, John-Michael, Hooser, Stephen B., Badger, Drew A., Baines, Antonio, Sipes, I. Glenn

Journal:

Drug Metabolism Reviews

Année:

1995

Langue:

english

Fichier:

PDF, 2.70 MB

english, 1995

25

[Advances in Pharmacology] Volume 43 || The Liver as a Target for Chemical-Chemical Interactions

Sauer, John-Michael

Année:

1997

Langue:

english

Fichier:

PDF, 1.48 MB

english, 1997

26

Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats

Burch, Peter M., Hall, D. Greg, Walker, Elizabeth G., Bracken, William, Giovanelli, Richard, Goldstein, Richard, Higgs, Richard E., King, Nicholas M.P., Lane, Pamela, Sauer, John-Michael, Michna, Laur

Journal:

Toxicological Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 1019 KB

english, 2015

27

Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury

Phillips, Jonathan A., Holder, Daniel J., Ennulat, Daniela, Gautier, Jean-Charles, Sauer, John-Michael, Yang, Yi, McDuffie, Eric, Sonee, Manisha, Gu, Yi-Zhong, Troth, Sean P., Lynch, Karen, Hamlin, Di

Journal:

Toxicological Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 439 KB

english, 2016

28

Promoting Adoption of the 3Rs through Regulatory Qualification

Walker, Elizabeth Gribble, Baker, Amanda F., Sauer, John-Michael

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 85 KB

english, 2016

29

Net Reclassification Index and Integrated Discrimination Index Are Not Appropriate for Testing Whether a Biomarker Improves Predictive Performance

Burch, Peter M., Glaab, Warren E., Holder, Daniel J., Phillips, Jonathan A., Sauer, John-Michael, Walker, Elizabeth G.

Journal:

Toxicological Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 83 KB

english, 2016

30

Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments

Schomaker, Shelli, Potter, David, Warner, Roscoe, Larkindale, Jane, King, Nicholas, Porter, Amy C., Owens, Jane, Tomlinson, Lindsay, Sauer, John-Michael, Johnson, Kent, Aubrecht, Jiri, Avila, Matias A

Journal:

Année:

2020

Fichier:

PDF, 914 KB

2020

31

The Regulatory Acceptance of Translational Safety Biomarkers

Sauer, John-Michael, Porter, Amy C.

Journal:

Current Opinion in Toxicology

Année:

2020

Fichier:

PDF, 3.30 MB

2020